4/20/2023 0 Comments High intensity focused ultrasound![]() ![]() PRFS temperature maps show that a (c) multi-baseline PRFS reconstruction allows stable and homogeneous temperature measurements, compared to a (b) single baseline (a) A coronal slice is acquired and shows the left and right kidney organs which are indicated with blue dashed lines. The result of healthy volunteer experiments without heating (volunteer #1). Simulations with a virtual motion phantom were performed to investigate the influence of the number of baselines and respiratory rate on the accuracy of temperature measurement. The pipeline supports multi-slice acquisition with minimal reconstruction lag.The application includes a fast spiral MRI pulse sequence and a real-time reconstruction pipeline based on multi-baseline proton resonance frequency shift (PRFS) method with visualization of temperature imaging.This project proposed an effective and practical reconstruction pipeline to achieve motion-robust, multi-slice, real-time MR thermometry for monitoring thermal therapy in abdominal organs.Osteoid osteoma: upcoming trial, comparison to RF-ablation.Palliation of painful bone metastases (commercial and clinical trial).We are currently enrolling patients in clinical trials using focused ultrasound for the treatment of brain tumors, psychiatric illnesses, bone tumors, and others. UCSF is a premier site for clinical trial enrollment and investigation because of strong collaborations between the scientific and clinical enterprises. UCSF is consistently ranked amongst the top hospitals for treatment of a wide variety of conditions. FUS-induced blood-brain barrier opening.Effect of sonication duration on ablation depth.Cardiac ablation with high-intensity ultrasound.MRI-guided focused ultrasound is being investigated as a powerful modality to treat a wide variety of conditions and applications, including movement disorders (such as essential tremor and Parkinson’s disease), brain tumors (such as glioblastoma and brain metastases), bone tumors (including osteoid osteoma), desmoid tumors, and psychiatric illness. Real time integration (RTHawk) with InSightec system.Sonication strategies for volumetric ultrasound hyperthermia.Motion-robust, multi-slice, real-time MR thermometry in abdominal organs.Research in those areas will provide promise for treating a wide range of oncological and neurological diseases. We have projects to develop MRI-guided focused ultrasound techniques for hyperthermia, high-intensity focused ultrasound (HIFU), and low-intensity focused ultrasound (LIFU). Our research is focused on the development of new advances in MR imaging methodology, real-time data acquisition/reconstruction, and therapeutic ultrasound techniques. ![]()
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